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Volume : III, Issue : XII, January - 2014

“PREPRATON AND CHARACTERIZATION OF STEROIDLINKED DERIVATIVES AS ANTICANCER AGENTS”

M. D. Sangale, A. S. Daptare

By : Laxmi Book Publication

Abstract :

The biological activity of progesterone is mediated by the progesterone receptor [PR], a member of the large gene family of nuclear receptors, which induces a cascade of transcriptional events after binding with the hormone. PR contains three functional domains including the N-terminus, a centrally located DNA binding domain (DBD) and C-terminal ligand binging domain (LBD) respectively. The binding of progesterone induces of conformational change in PR that promotes dissociation from a multi-protein complex followed by homo dimerization and binding to specific progesterone response elements (PRE) within the promoter genes. The hormone activated PR recruits co-activators through protein-protein interactions, which serve as intermediates for the initiation of transcriptional processes.

Keywords :


Article :


Cite This Article :

M. D. Sangale, A. S. Daptare(2014). “PREPRATON AND CHARACTERIZATION OF STEROIDLINKED DERIVATIVES AS ANTICANCER AGENTS”. Indian Streams Research Journal, Vol. III, Issue. XII, http://isrj.org/UploadedData/4078.pdf

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  202. Mosselman S, Polman J and Dijkema R,FEBS Lett., 392,49-53 (1996)
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  212. Ries L, et al. SEER Cancer Statics REVIEW, 10, 1973-1996(1999)
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  214. Korach K, Science,266, 1524-1527 (1994)
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  216. Korach K, Science,266, 1524-1527 (1994)
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